Neurodegenerative diseases, such as Alzheimer's disease or frontotemporal degeneration, lead to the progressive loss of neurons. Alzheimer's disease alone affects approximately 30% of people over 85 years old and its prevalence is increasing due to an aging population. Although, no cure is available for neurodegenerative diseases, some drugs can alleviate symptoms and slow down symptom onset and even disease progression. Early diagnosis is therefore critical for maintaining a patient's quality of life as long as possible.
Unfortunately, the disease might go undetected in its early stages, as the patient often does not yet show any clinical symptoms. However, molecular markers, functional and structural changes might already be present and might help with early diagnosis. Research at the Department of Neuroradiology therefore focuses on the detection of these early changes. Another focus lies on investigating disease progression in multiple sclerosis.
We use standardized, high resolution, multiparametric MRI data for quantitative functional analysis (ASL MR-perfusion, MR-spectroscopy, fMRI), and structural analysis of grey and white matter (high resolution 3D T1/T2, DTI, morphometry, segmentation).
Imaging gait analysis: An fMRI
dual task study. Bürki
CN, Bridenbaugh SA, Reinhardt J, Stippich C, Kressig RW, Blatow M. Brain Behav. 2017 Jul 21;7(8):e00724. LINK
Parietal lobe critically supports
successful paired immediate and single-item delayed memory for targets. Krumm
S, Kivisaari SL, Monsch AU, Reinhardt J, Ulmer S, Stippich C, Kressig RW, Taylor KI. Neurobiol Learn Mem. 2017 May;141:53-59. LINK
Association between changes in
cerebral grey matter volume and postoperative cognitive dysfunction in elderly
patients: study protocol for a prospective observational cohort study.
Mistridis P, Berres M, Reinhardt J, Stippich
C, Monsch AU, Steiner LA. BMC Anesthesiol. 2016 Nov 25;16(1):118. LINK
Neuropsychological Markers of
Medial Perirhinal and Entorhinal Cortex Functioning are Impaired Twelve Years
Preceding Diagnosis of Alzheimer's Dementia. Hirni
DI, Kivisaari SL, Krumm S, Monsch AU, Berres M, Oeksuez F, Reinhardt J, Ulmer
S, Kressig RW, Stippich C,
Taylor KI. J Alzheimers Dis. 2016 Mar
Cortical thinning of
parahippocampal subregions in very early Alzheimer's disease. Krumm
S, Kivisaari SL, Probst A, Monsch AU, Reinhardt J, Ulmer S, Stippich C, Kressig RW, Taylor KI. Neurobiol Aging. 2016 Feb;38:188-196. LINK
Comparison between balanced steady-state free precession and standard spoiled gradient echo magnetization transfer ratio imaging in multiple sclerosis: methodical and clinical considerations. Amann M, Sprenger T, Naegelin Y, Reinhardt J, Kuster P, Hirsch JG, Kappos L, Radue EW, Stippich C, Bieri O. Neuroimage. 2015 Mar;108:87-94. LINK